6,350 research outputs found

    Sequential Implementation of Monte Carlo Tests with Uniformly Bounded Resampling Risk

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    This paper introduces an open-ended sequential algorithm for computing the p-value of a test using Monte Carlo simulation. It guarantees that the resampling risk, the probability of a different decision than the one based on the theoretical p-value, is uniformly bounded by an arbitrarily small constant. Previously suggested sequential or non-sequential algorithms, using a bounded sample size, do not have this property. Although the algorithm is open-ended, the expected number of steps is finite, except when the p-value is on the threshold between rejecting and not rejecting. The algorithm is suitable as standard for implementing tests that require (re-)sampling. It can also be used in other situations: to check whether a test is conservative, iteratively to implement double bootstrap tests, and to determine the sample size required for a certain power.Comment: Major Revision 15 pages, 4 figure

    Do early-life exposures explain why more advantaged children get eczema? Findings from the U.K. Millennium Cohort Study

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    Background: Atopic dermatitis (eczema) in childhood is socially patterned, with higher incidence in more advantaged populations. However, it is unclear what factors explain the social differences. Objectives: To identify early-life risk factors for eczema, and to explore how early-life risk factors explain any differences in eczema. Methods: We estimated odds ratios (ORs) for ever having had eczema by age 5 years in 14 499 children from the U.K. Millennium Cohort Study (MCS), with a focus on maternal, antenatal and early-life risk factors and socioeconomic circumstances (SECs). Risk factors were explored to assess whether they attenuated associations between SECs and eczema. Results: Overall 35·1% of children had ever had eczema by age 5 years. Children of mothers with degree-level qualifications vs. no educational qualifications were more likely to have eczema (OR 1·52, 95% confidence interval 1·31–1·76), and there was a gradient across the socioeconomic spectrum. Maternal atopy, breastfeeding (1–6 weeks and ≥ 6 months), introduction of solids under 4 months or cow's milk under 9 months, antibiotic exposure in the first year of life and grime exposure were associated with an increased odds of having eczema. Female sex, Pakistani and Bangladeshi ethnicity, smoking during pregnancy, exposure to environmental tobacco smoke and having more siblings were associated with reduced odds for eczema. Controlling for maternal, antenatal and early-life characteristics (particularly maternal smoking during pregnancy, breastfeeding and number of siblings) reduced the OR for eczema to 1·26 (95% confidence interval 1·03–1·50) in the group with the highest educational qualifications compared with the least. Conclusions: In a representative U.K. child cohort, eczema was more common in more advantaged children. This was explained partially by early-life factors including not smoking during pregnancy, breastfeeding and having fewer siblings

    Stability of continuously pumped atom lasers

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    A multimode model of a continuously pumped atom laser is shown to be unstable below a critical value of the scattering length. Above the critical scattering length, the atom laser reaches a steady state, the stability of which increases with pumping. Below this limit the laser does not reach a steady state. This instability results from the competition between gain and loss for the excited states of the lasing mode. It will determine a fundamental limit for the linewidth of an atom laser beam.Comment: 4 page

    Differentiating Disclosure and Concealment in Measurement of Outness for Sexual Minorities: The Nebraska Outness Scale

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    Research on lesbian, gay, and bisexual (LGB) individuals has long examined outness, or openness about one’s sexual orientation, as an important predictor of health and well-being. The authors reconceptualized outness as a composite of two related but independent constructs: disclosure and concealment of sexual orientation. This conceptualization guided creation of the Nebraska Outness Scale (NOS), a 10-item measure with a concealment (NOS-C) and disclosure (NOS-D) subscale. The scale and subscales showed good internal reliability, discriminant, convergent, and predictive validity. As hypothesized, concealment showed a stronger relationship to mental health and well-being constructs than disclosure. Disclosure, but not concealment, also differed across sexual orientations with bisexual individuals reporting less disclosure and mostly gay/lesbian and gay/lesbian individuals reporting successively higher levels. The authors conclude that concealment and disclosure are separate constructs and that concealment may be more relevant to minority stress processes among LGB individuals and may provide a more comparable measure across sexual orientation categories. Further research is needed to validate the scale and to examine the role that outness plays in minority stress among LGB individuals

    A Space of Transition: Rethinking Surrogates

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    The knowledge organization (KO) process of representing something identifiable typically involves creating a surrogate. The surrogate brings together the thing and the knowledge organization system (KOS). Therefore, we decided to focus on the surrogate and its role in the process of representation. In current practice KOS govern the creation of the surrogate. This something being represented is typically, but not necessarily, an information resource. It may also be artistic, tangible, spiritual, etc., knowledge organization systems meant to organize surrogates that represent something identifiable. A knowledge organization professional (KOP) selects what aspects of the thing to include in the representation. The knowledge organization experts/establishment (KOE) are responsible for the development of the context in which surrogates are created. The KOE are key drivers in determining process, and in developing and maintaining standards. Traditional practices are intended to ensure consistency and uniformity of interpretation and application across a range of physical and digital discourses. This context can be considered anew as postcolonial critic Homi Bhabha’s concept of the Third Space (1994)
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